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Wnt Signaling (GRS)

Gordon Research Seminar

Mechanisms, Biology, and Therapy

June 21 - 22, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Bates College

2 Andrews Road

Lewiston, Maine, United States

Venue and Travel Information

Venue

Office Manager: D'Angelina Mbalire

Office Manager Email: bates_sm@grc.org

Office Phone:

Conference Description

The Wnt Signaling GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Related Meeting

This GRS will be held in conjunction with the "Wnt Signaling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Linking Four-Winged Flies with Cancer Research Discussion Leader:
3:45 pm - 4:20 pm	"From Four-Winged Flies to Cancer"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms and Therapeutics Discussion Leader:
7:30 pm - 7:40 pm	"Frizzled Receptors: Potential Multipass γ-Secretase Substrates"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Cell Identity Decisions in the Intestinal Epithelium: A WNT-WNT Situation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Bypassing β-Catenin: Direct Targeting of TCF/LEF Transcription Factors"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Deciphering the Role of Lipidation in Non-Canonical Versus Canonical Wnt Secretion and Signaling"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Distinct IDR-Mediated Condensates of TCF3 and LEF1 Differentially Regulate Wnt-Specific Transcriptional Activity"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Image-Based Screens Identify Regulators of Endogenous Dvl2 Biomolecular Condensates"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Calcifying Extracellular Vesicle Release"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Glycosaminoglycan-Mediated Transport and Action of Wnts"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Development, Regeneration and Disease Discussion Leader:
9:00 am - 9:10 am	"Generating Cardiac Lineage Cells From PLN Patient-Derived Human Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery to Study Cardiomyopathic Functional and Molecular Dysfunction"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Wnt/β-Catenin Coordinates Muscle Spindle Development by Regulating Capsule Differentiation, Intrafusal Fiber Nuclei Aggregation, and Proprioceptive Nerve Endings"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"The Role of Developmental Wnt Signaling in Aberrant Adult Hematopoiesis"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Delineating the Role of Tumor-Intrinsic WNT Signaling on Immune Cell Function Using CRC Organoids"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Decoding Tooth Morphogenesis in Wnt10a^-/-Mice via Spatial Transcriptomics"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Mapping the Genetic Interaction of Hyperactive ß-catenin in Colorectal Cancer"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"DVL1 Regulates Global Transcriptomic Changes and Associates With the Transcription Factor ETS1"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Proximity Labeling and CRISPRi Screening Reveals Novel Regulators of Wnt Signaling"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Innovative and Disruptive Science in Academia and Industry Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion Innovative and Disruptive Science in Academia and Industry
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD118732. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Wnt Signaling Contribute Financially to This Conference

Conference Fees

Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$275.00

Conferee Shared Room:

$260.00

Conferee Off-Site:

$210.00

Guest Single Room:

$275.00

Guest Shared Room:

$260.00

Guest Off-Site:

$210.00

Child 4-12 yrs Shared Room:

$131.00

Child 4-12 yrs Off-Site:

$106.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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