Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspective — Integrative Biology of Aging
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:35 pm
"mTOR Signaling in Growth and Metabolism"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Short-Term mTORC1 Inhibition Regulates Key Components of the Aging Gene Expression Signature"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Age-Induced Expression of Notum in the Stem Cell Niche Attenuates Regenerative Potential of Intestinal Epithelium"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fragility
in Aging: Mitochondria and ER
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Mitochondrial Stress Signaling in Aging, Disease and Immunity"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Contextual Roles for Mitochondrial Network States in Longevity"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Microbiome and Gut Mitochondria in Longevity Control in C. elegans "
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Promoting Drp1-Mediated Mitochondrial Fission in Midlife Facilitates Mitophagy and Increases Healthy Lifespan"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation and Epithelial Senescence"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"mTOR-Dependent Translation Control Switches in Slow-Aging Mutant Mice"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Fragility
in Aging: Epigenetics
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Modeling Aging of Human Neurons via Neuronal Reprogramming of Somatic Cells"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Cell-Cell Communication in Senescence"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Anti-Aging Interventions Versus Epigenetic Aging"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Perturbation: Inflammation, Metabolism, and Aging
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"The Metabolome as a Bridge Between Genotype and Phenotype"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Life Span Modulation by Gut Microbiota Transfer in the Naturally Short-Lived African Turquoise Killifish"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"A Novel siRNA Signal Promotes Longevity and Heat Shock Response in C. elegans "
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Upregulation of MicroRNA-150 in Aged Macrophages Promotes Age-Related Macular Degeneration"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Age-Associated Clonal Dominance of Myeloid-Biased HSC Is Underwritten by Unique Transcriptional and Epigenetic Alterations"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Small Nucleoli Are a Cellular Hallmark of Longevity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Perturbation: Biological Rhythm and Aging
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Hypothalamic Sirtuins and mTOR Signaling Pathway: A Key Regulator of Sleep, Aging and Longevity"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Positive Feedback Between the Arabidopsis Aging Regulator ORE1 and Circadian Clock Components Promotes Robust Rhythmicity"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Circadian Regulation of Aging and Mitochondrial Uncoupling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Robustness: Stress and Damage Responses
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"The Roles and Mechanisms of Cellular Senescence in Aging-Associated Cancer"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"SIRT6 Mediates Coevolution of DNA Repair and Longevity in Rodents"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Cellular Quality Control in C. elegans "
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Elucidating the In Vivo Impact of Senescent Cells to Age-Related Diseases"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The Hh Signalling Pathway Modulates Lifespan Determination and Neuroprotection in Drosophila "
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Chromatin Rearrangements and Endogenous Retroelements De-Repression During Cellular Senescence"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Robustness: Proteostasis and Autophagy
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Autophagy and Aging: Lessons from Long-Lived Animals"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Proteostasis and Age-Associated Neurodegeneration"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Maintaining Cellular Homeostasis in Skeletal Muscle with Aging and Disease"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Conserved KLF-Autophagy Pathway Modulates Nematode Lifespan and Mammalian Age-Associated Vascular Dysfunction"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Systemic Regulation of Aging and Longevity
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Systemic Regulation of Brain Aging and Neurodegeneration"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Regulators of Myofiber Size and Sarcopenia"
10:10 am - 10:20 am
Discussion
10:20 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Understanding Muscle Stem Cell Regenerative Decline with Aging"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Longevity, Healthy Ageing and Disease. The Metabolome as a Biomarker"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Offspring Aging Is Transgenerationally Determined by Maternal Age and Diet"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interventions
for Productive Aging
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Fasting Mimicking Diets and Multi-System Regeneration"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Nicotinamide Riboside Metabolism: Roles in Health and Disease"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Klotho and Brain Resilience"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure