Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Molecular Mechanisms of Aging and Longevity
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Successful Neuronal Aging and Proteostasis: It Takes a Village"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Age-Related Changes in Gene Expression and Signaling in Mice and Rats: Including Changes in Activin Signaling and Mitochondria Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mitochondria-Lysosome Coupling Contributes to Lysosome Acidification and Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The tRNA Pool Regulates Translation Fidelity During Aging"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Understudied Species and New Models for Aging Research
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Dogs as a Translational Model for the Biology of Aging"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Equine Clinical Models of Naturally Occurring Miscarriage: A Unique Lens into Reproductive Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Epigenetic and Reproductive Stability Through Lifespan in the Axolotl"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Comparative Lipidomics Reveals Molecular Signatures of Lifespan Across Mammals"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Aging and Whole-Body Rejuvenation in Extremely Long-Lived Planarians"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Gerotherapeutic Intervention with Rapamycin to Target Aging and Health in Non-Human Primates"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Age-Related Decline of Heat Stress Tolerance in the Fast-Aging African Killifish"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Greenland Shark, Somniosus Microcephalus, Genome Provides Insights Into Extreme Longevity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Comparative Biology of Aging
6:00 pm - 6:20 pm
"Impact of Population Dynamics on the Genetics of Aging"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Bat Longevity and Epigenome Stability"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Multi-Omic Biomarkers of Longevity Across Species"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Introns Sequences are Modulators of Ribosome Biogenesis and Determinants of Mammalian Longevity"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Aging of the Hematopoietic Stem Cell Compartment"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Temperature and Aging Biology"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Mechanisms of Ovarian Aging: A Target for Geroprotection in Women"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reproductive History and Ovarian Aging"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Naked Mole-Rat as a Model of Reproductive Aging"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"In Vivo Modeling of Ovarian Aging and Accelerated Functional Genetics by Adeno-Associated Viruses (AAVs)"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Understanding Tissue Dynamics of the Aging Murine Ovary"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alternative Splicing and the Decline of Reproductive Fitness with Age"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"The Laying Hen Makes Some Noise"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Inflammation, Transposable Elements and Aging
6:00 pm - 6:20 pm
"Programming and Reprogramming of Aging"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Exploring the Dark Genome: Somatic Retrotransposition in Cellular Senescence, Aging and Disease"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Regulation of Active LINE1 Elements Prolongs Lifespan and Healthspan in Mice While Enhancing Reproductive Longevity"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Molecular Underpinnings of Exercise's Health-Promoting and Geroprotective Effects"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Genetically Engineered MDSCs and uPAR CAR-T Cells as Novel Immunotherapeutic Strategies for Rheumatoid Arthritis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics and Nuclear Architecture During Aging
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"From Biomarker Discovery to a Candidate Therapeutic for Alzheimer’s Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Epigenetic Alterations Drive Stem Cell Aging"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"SIRT6 Promotes Epigenome Stability and Reduces Frailty"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Measuring Aging with AI"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Uncovering The Missing X Factors and Their Function to Understand Sex Bias in Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hematopoietic Loss of the Y Chromosome: A Determinant of 'Inflammaging' in Men"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"G-Quadruplexes in Aging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Sleep Mimetics: Unlocking the Power of Restorative Sleep for Healthy Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Technologies and Omics Approaches in Aging
6:00 pm - 6:20 pm
"Genomic Signatures of Human Immune System Aging and Reduced Vaccine Responses"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Age-Associated Somatic DNA Copy Number Alterations at Single-Cell Resolution"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Genomic Basis of Longevity"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Blood Multiomic Profiles Reflect System States of Organs in Mice"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Exploring Ribosomal RNA Modifications and Corresponding snoRNAs in Human Skin Cell Senescence"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"An Actionable Immune Age Model of T Cell Activity"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Anti-Aging Interventions, Human Aging and Stem Cells
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Anti-Aging Drugs and the Search for Shared Mechanisms"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Purine-Pyrimidine Balance is Regulated by XMP Levels and Determines the Dietary Restriction Phenotype"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Niche-Specific Macrophage Loss Promotes Skin Capillary Aging"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"SIRT6 Activator Fucoidan Extends Healthspan and Lifespan in Aged Wild-Type Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Transcriptional and Epigenetic Mechanisms of Brain Aging and Neurodegeneration"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Targeting Cellular Cross-Talks in Cardiac Aging"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Polyamines Sustain Epithelial Regeneration in Aged Intestines by Modulating Protein Homeostasis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Glucocorticoid Rhythms Enhance the Metabolic Benefits of Caloric Restriction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Specific Wavelengths of Near Infrared Light Promote Mitochondrial Quality Control"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"DNA Methylation-Based Semen Age Prediction"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Inter Organ Communication During Aging
6:00 pm - 6:20 pm
"Harnessing Beneficial Senescence to Improve Health and Lifespan"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Sexual Dimorphism in Immunity and Ageing"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Remodeling of the ER as a Mechanism of Aging"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Organ Communication in Aging of Zebrafish"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Slow Gompertzian Aging in Long-Lived C. Elegans Results from Expansion of Decrepitude, Not Decelerated Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
