Sunday
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2:00 pm - 9:00 pm |
Arrival and Check-in
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6:00 pm - 7:00 pm |
Dinner
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7:30 pm - 7:40 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
|
7:40 pm - 9:30 pm |
Tetrapyrroles: Chemistry and Catalysis
Discussion Leader: Judith Burstyn (University of Wisconsin-Madison, USA)
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7:40 pm - 7:45 pm |
Opening Remarks
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7:45 pm - 8:10 pm |
Yoshitsugu Shiro (University of Hyogo, Japan)
"Coordination and Electronic Structures of Short-Lived Intermediate in Heme-Containing NO Reductases"
|
8:10 pm - 8:20 pm |
Discussion
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8:20 pm - 8:45 pm |
Diana Imhof (Pharmaceutical Institute, University of Bonn, Germany)
"Unraveling the Chemistry of Reversible Heme Binding"
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8:45 pm - 8:55 pm |
Discussion
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8:55 pm - 9:20 pm |
Koichiro Ishimori (Hokkaido University, Japan)
"Unusual Heme Binding and Its Functional Significance in Heme-Regulated Proteins"
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9:20 pm - 9:30 pm |
Discussion
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Monday
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7:30 am - 8:30 am |
Breakfast
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9:00 am - 12:30 pm |
Heme Synthesis and Pathophysiology
Discussion Leader: Jean-Charles Deybach (Paris Diderot University, France)
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9:00 am - 9:25 am |
Herve Puy (Hôpitaux Universitaires Paris Nord Val de Seine, France)
"ALA Synthases and Their Substrates: The Heme Gatekeepers"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Amy Simon (Alnylam Pharmaceuticals, USA)
"RNAi Therapeutics for Acute Hepatic Porphyrias"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:35 am |
Coffee Break
|
10:35 am - 11:00 am |
Miguel Soares (Fundacao Calouste Gulbenkian, Instituto Gulbenkian de Ciencia, Portugal)
"Heme in Infection"
|
11:00 am - 11:10 am |
Discussion
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11:10 am - 11:35 am |
Rajiv Ratan (Burke Neurological Institute, Weill Cornell Medicine, USA)
"Adaptive Responses to Heme-Induced Neuronal Stress: SEeing Is Believing"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Selected from Poster Abstracts: Yvette Yien (University of Delaware, USA)
"FAM210B Is an Erythropoietin Target and Regulates Erythroid Heme Synthesis"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Caiyong Chen (Zhejiang University, China)
"TNGO-2 Regulates Cellular Heme Homeostasis in Metazoa"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:30 pm |
Poster Previews
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
3:00 pm - 4:00 pm |
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Emma Raven (University of Leicester, United Kingdom) and Amy Medlock (University of Georgia, USA)
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Regulatory Pathways in Chlorophyll and Energy Production
Discussion Leader: Mats Hansson (Lund University, Sweden)
|
7:30 pm - 7:55 pm |
Bernhard Grimm (Humboldt-Universität Berlin, Germany)
"Multiple Posttranslational Control Mechanisms on Glutamyl-tRNA Reductase"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Ayumi Tanaka (Hokkaido University, Japan)
"Regulation of Chlorophyll Metabolism by Mg-Dechelatase"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 9:05 pm |
Carl Bauer (Indiana University, USA)
"Redox and Light Control of Tetrapyrrole Synthesis in an Anoxygenic Phototroph"
|
9:05 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Nathan Adams (The University of Sheffield, United Kingdom)
"Bridging the Gap: How Magnesium Chelatase Harnesses ATP Hydrolysis to Power Metal Ion Insertion"
|
9:25 pm - 9:30 pm |
Discussion
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Tuesday
|
7:30 am - 8:30 am |
Breakfast
|
8:30 am - 9:00 am |
Group Photo
|
9:00 am - 12:30 pm |
Heme Trafficking and Imaging
Discussion Leader: Michael Marletta (University of California, Berkeley, USA)
|
9:00 am - 9:25 am |
Robert Kranz (Washington University in St. Louis, USA)
"Heme Trafficking and Modification in Cytochrome c Biogenesis"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Amit Reddi (Georgia Institute of Technology, USA)
"Heme Gazing: Elucidating Heme Trafficking and Signaling with Fluorescent Heme Sensors and Affinity Reagents"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:35 am |
Coffee Break
|
10:35 am - 11:00 am |
Jacquin Niles (Massachusetts Institute of Technology, USA)
"Quantifying Heme Levels in Malarial Parasites Through Imaging"
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:35 am |
Ji-Xin Cheng (Boston University, USA)
"Label-Free Transient Absorption Imaging of Heme Storage, Transport, and Modifications"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Selected from Poster Abstracts: Rini Pek (University of Maryland, USA)
"Heme Transport and Recycling "
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Angela Fleischhacker (University of Michigan, USA)
"The Heme Regulatory Motifs of Heme Oxygenase-2 Function to Transfer Heme to the Catalytic Site for Degradation"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Elizabeth Sweeny (Lerner Research Institute, Cleveland Clinic, USA)
"GAPDH Regulates Allocation of Bioavailable Heme in Cells"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Linear Tetrapyrroles and Photoreceptors
Discussion Leader: Nicole Frankenberg-Dinkel (TU Kaiserslautern, Germany)
|
7:30 pm - 7:55 pm |
Donald Bryant (Pennsylvania State University, USA)
"Life on the (Far)-Red-Edge of Darkness: How Terretrial Cyanobacteria Sense and Respond to Far-Red Light"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Rei Narikawa (Shizuoka University, Japan)
"Functional Diversification of Two Bilin Reductases for Photoperception and Photosynthesis in a Unique Cyanobacterium Acaryochloris marina"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 9:05 pm |
Wendy Schluchter (University of New Orleans, USA)
"Type IV Chromatic Acclimation in Marine Synechococcus"
|
9:05 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Matthew Liptak (University of Vermont, USA)
"Spectroscopic Evidence for Electronic Control of Heme Hydroxylation by IsdG"
|
9:25 pm - 9:30 pm |
Discussion
|
Wednesday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Biosynthesis, Trafficking and Homeostasis of B12 and Corrinoids
Discussion Leader: Alison Smith (University of Cambridge, United Kingdom)
|
9:00 am - 9:25 am |
Nigel Robinson (Durham University, United Kingdom)
"The Partitioning of Metals in Tetrapyrrole Biosynthesis"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Michiko Taga (University of California, Berkeley, USA)
"Cofactor Specificity in Corrinoid-Dependent Bacteria"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:35 am |
Coffee Break
|
10:35 am - 11:00 am |
Ruma Banerjee (University of Michigan, USA)
"B12 Trafficking and Its Modulation by Itaconate"
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:35 am |
Aaron Wright (Pacific Northwest National Laboratory, USA)
"Elucidating the Mechanistic Underpinnings of Cobalamin in Microbial Cell Growth, Gene Regulation, and Enzyme Activity"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Selected from Poster Abstracts: Felix Zelder (University of Zurich, Switzerland)
"Cobalamins for Biomimetic Studies and Medicinal Applications"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Henry Bailey (University of Oxford, United Kingdom)
"Structure of Human Aminolevulinate Synthase Reveals a Strong Evolutionary Divergence in C-Terminal Regulation"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Andrew Sayer (University of Cambridge, United Kingdom)
"Investigating the Molecular Basis of Vitamin B12 Uptake in Algae"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:00 pm - 7:30 pm |
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
|
7:30 pm - 9:30 pm |
Tetrapyrroles: Degradation and Signaling
Discussion Leader: Angela Wilks (University of Maryland, USA)
|
7:30 pm - 7:55 pm |
Elizabeth Boon (Stony Brook University, USA)
"Discovery of NO-Responsive Hemoproteins and Their Roles in Biofilm Regulation"
|
7:55 pm - 8:05 pm |
Discussion
|
8:05 pm - 8:30 pm |
Vladislav Verkhusha (Albert Einstein College of Medicine, USA)
"Near-Infrared Fluorescent Proteins, Biosensors and Optogenetic Tools Engineered from Bacterial Phytochromes"
|
8:30 pm - 8:40 pm |
Discussion
|
8:40 pm - 9:05 pm |
Michael Bauer (Jena University Hospital, Germany)
"Heme, Bile Bigments and Beyond: Bilirubin Oxidation Products and Liver Function Under Stress Conditions"
|
9:05 pm - 9:15 pm |
Discussion
|
9:15 pm - 9:25 pm |
Selected from Poster Abstracts: Susana Mouriño Lopez (University of Maryland, Baltimore, USA)
"The Extracellular Heme Sensor HasAp Is Central to Heme Metabolism and Virulence"
|
9:25 pm - 9:30 pm |
Discussion
|
Thursday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am - 12:30 pm |
Tetrapyrroles at the Host-Pathogen Interface
Discussion Leader: Celia Goulding (University of California, Irvine, USA)
|
9:00 am - 9:25 am |
Pedro Oliveira (Universidade Federal do Rio de Janeiro, Brazil)
"Heme-Induced Cell Signaling in Aedes aegypti"
|
9:25 am - 9:35 am |
Discussion
|
9:35 am - 10:00 am |
Jose Maria Perez-Victoria (Instituto de Parasitologia y Biomedicina "Lopez-Neyra", CSIC, Spain)
"Porphyrin Trafficking and Metabolism in Trypanosomatid Protozoan Parasites"
|
10:00 am - 10:10 am |
Discussion
|
10:10 am - 10:35 am |
Coffee Break
|
10:35 am - 11:00 am |
Delphine Lechardeur (Micalis Institute, INRA, France)
"Impact of Heme in the Host-Pathogen Relationship"
|
11:00 am - 11:10 am |
Discussion
|
11:10 am - 11:35 am |
Paul Sigala (University of Utah School of Medicine, USA)
"Heme Utilization by Blood-Stage Malaria Parasites"
|
11:35 am - 11:45 am |
Discussion
|
11:45 am - 11:55 am |
Selected from Poster Abstracts: Hanna Kwon (University of Leicester, United Kingdom)
"Neutron Structure of a Peroxidase-Substrate Complex Reveals Neutral Arginine in Proton Pathway"
|
11:55 am - 12:00 pm |
Discussion
|
12:00 pm - 12:10 pm |
Selected from Poster Abstracts: Breann Brown (Massachusetts Institute of Technology, USA)
"Structural Investigation of Determinants Mediating ALAS Cofactor Binding"
|
12:10 pm - 12:15 pm |
Discussion
|
12:15 pm - 12:25 pm |
Selected from Poster Abstracts: Zhicheng Dou (Clemson University, USA)
"Toxoplasma gondii, an Obligate Intracellular Protozoan Pathogen, Relies on Its own Heme Biosynthesis for Infection"
|
12:25 pm - 12:30 pm |
Discussion
|
12:30 pm - 1:30 pm |
Lunch
|
1:30 pm - 4:00 pm |
Free Time
|
4:00 pm - 6:00 pm |
Poster Session
|
6:00 pm - 7:00 pm |
Dinner
|
7:30 pm - 9:30 pm |
Keynote Session: Tetrapyrrole Homeostasis: From Microbes to Man
Discussion Leader: Mark O'Brian (University at Buffalo, USA)
|
7:30 pm - 7:35 pm |
Introduction by Discussion Leader
|
7:35 pm - 8:15 pm |
Martin Warren (University of Kent, United Kingdom)
"Macrocyclic Tetrapyrroles: The 72 Steps to the Pigments of Life"
|
8:15 pm - 8:30 pm |
Discussion
|
8:30 pm - 8:35 pm |
Introduction by Discussion Leader
|
8:35 pm - 9:15 pm |
David Rosenblatt (McGill University, Canada)
"Biological Lessons from Patients with Inherited Disorders of Cobalamin Metabolism"
|
9:15 pm - 9:30 pm |
Discussion
|
Friday
|
7:30 am - 8:30 am |
Breakfast
|
9:00 am |
Departure
|