Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Initiating Events in Hemostasis and Thrombosis
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Initiation of Contact Activation"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mechanisms of Platelet Alpha and Dense Granule Biogenesis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Contact Pathway Activation and Polyphosphate"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Contributions from the Blood and Vasculature
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Regulation of Endothelial Exocytosis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Making and Measuring the Effect of Mutations on a Massive Scale"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:15 am
"Fibrin/GPVI Interactions in Thrombosis and Hemostasis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Combining Immunohematology and Biophysics to Better Understand Immune-Mediated Blood Cell Disorders: Lessons Learned from HIT"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A Chromosome 5 Cis-Regulatory Element Regulates Mouse Platelet PAI-1 Expression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Interactions Between Blood and Platelets
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Role of Aging and Inflammation in Platelet Activation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Emerging Concepts in Immune-Mediated Thrombotic Thrombocytopenic Purpura"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Platelet/Fibrin Interactions During Thrombosis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Contributions to Hemostasis and Thrombosis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Alterations in von Willebrand Factor and Redox State in Sickle Cell Disease"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Zymogen Factor XII and Neutrophil Functions"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"The Dynamics of Protease Activated Receptor (PAR) Activation and Signaling"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Role of VWF Glycans in Regulating Clearance"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mechanisms of Altered Platelet Production During Inflammation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advanced Models of Coagulation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Insights into the Pathophysiology of Thrombosis Using Mice with Impaired Anticoagulation"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Regulating Intra-Clot Thrombin and Fibrin Production Under Flow"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mathematical Models of Coagulation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New and Emerging Therapeutic Targets
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Oral Therapy for Hemophilia"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Novel Anticoagulants Through Allosteric Regulation of Coagulation Proteases"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Targeting FXa with Aptamer-Small Molecule Active Site Inhibitor Pairs for Potent and Reversible Anticoagulation"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Assessing the Benefit of Emicizumab for the Treatment of Hemophilia A: From Lab to Label"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Platelet-Like Particles for Hemostasis and Wound Repair"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
"The Effect of Rigid Red Blood Cells on Platelet Margination and Adhesion in Flow"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Crystal Structure and Allosteric Activation of ADAMTS13"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Design of Biomaterials-Based Technologies for Intravenous Mitigation of Trauma-Associated Hemorrhage and Coagulopathy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Uncovering the Unique Functional APC-Resistant Modifications of Pseudonaja textilis Factor V"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Context Matters: Influence of the Physical Environment on the Spatial Distribution of Platelet Activation and Thrombin Activity During Hemostasis In Vivo "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"In Vivo Transcriptional Profiling of the Endothelium in a Novel Mouse Model of von Willebrand Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Development of Novel Anti-Fouling Molecular Probes to Detect New Platelet Ligands and Pathogenic Anti-Platelet Antibodies"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"BFPI: A Minimal Prothrombinase Inhibitor from the Saliva of Simulium vittatum "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Coagulation Mechanisms Beyond Hemostasis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanisms Coupling Hemostatic Factors to Tumorigenesis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:10 am
"The Role of Factor XIII-A in Energy Metabolism"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Coagulation in Sickle Cell Disease"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Role of Coagulation in Liver Injury and Repair"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The Anti-Thrombotic Effect of Aspirin Is Partially Transmissible via Gut Microbe Transplantation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Hemostasis and Thrombosis: Bench to Bedside
5:30 pm - 5:40 pm
Introduction by Discussion Leader
5:40 pm - 6:20 pm
"Antithrombotic Therapy: Today and Tomorrow"
6:20 pm - 6:35 pm
Discussion
6:35 pm - 7:15 pm
"Cellular Targets in Thrombosis"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure