Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Building the Lymphatic Vasculature
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Lymphatic Vessels in Organ Growth and Regeneration"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Using Enhancer Analysis to Delineate the Transcriptional Regulation of Early Lymphatic Development"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Developmental Origins of Lymphatic Endothelial Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Deciphering the Biophysical Rules that Govern Chromatin Navigation of the SOX18 Transcription Factor"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Lymphatics at the Barriers
9:00 am - 9:20 am
"Growth Factors in Lymphatic Development, Disease and Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Role of Meningeal Lymphatics in Immune Surveillance of the Brain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"In Vivo Imaging of Cerebrospinal Fluid Flow and Clearance Through Lymphatic Vessels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Pathogenic Mechanisms of Vascular Malformations"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Angiopoietin/Tie Signalling in Lymphangiogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Pulmonary Lymphatics: A Role in Lung Injury?"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Angiopoietin-Tie Signaling in Postnatal Lymphatic Vessel Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolism of Lymphatic Endothelial Cells
7:30 pm - 7:50 pm
"Lymphangiogenic Signaling Pathway Regulates Adipose and Hepatic Responses in Obesity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Macrophage and Regulation of Lymphatic Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Lymphatic Vasculature in Organ Growth"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Lymphatic Pathophysiology in Congenital Heart Disease with Increased Pulmonary Blood Flow"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Control of Lymphatic Expansion by FOXO Transcription Factors"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Mechanics of Lymphatics
9:00 am - 9:20 am
"Regulation of Lymphatic Vessel Integrity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms by Which Pressure Regulates Lymphatic Pumping"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Novel Associations Between Lymphedema and Cardiovascular Disorders"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lymphatic Junction Molecules as Signaling Regulators"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"BMP-SMADs Promote Lymphatic Vessel Stabilization by Tuning WNT Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Impact of the Space Environment on Lymphatic Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lymphatics and Statins: A Lova-Hate Story"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics and Pathophysiology of Rare Lymphatic Diseases
7:30 pm - 7:50 pm
"Dealing with Variants of Unknown Significance (VUS): Functional Characterization of Variants in Primary Lymphoedema Patients"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Heterogeneous Pathophysiological Basis of Primary Lymphedema"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sodium Imaging: Lessons Learned from Lipedema and Lymphedema"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Underlying Histological Characteristics of Lymphedema and Lipedema"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Lymphangiogenic Signaling in Diseases of the Cardio-Renal Axis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cell Navigation to and from Lymphatics
9:00 am - 9:20 am
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Leukocyte Migration and Immune Regulation Within Afferent Lymphatics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Integrin avβ3 Signaling Regulates Developmental Lymphangiogenesis in Mice"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Lymphatic Endothelial Cell Identity Is Controlled by a GATA2 Bound Enhancer"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Transport of Cellular and Molecular Cargo via Intestinal Lymphatics and Its Association with Inflammatory Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Role of the Lymphatic System in Cancer Progression"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Roles of Cardiac Lymphatic Vessels in Zebrafish Heart Development and Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Primordial Lymph Vessel Formation in the Mouse"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lymphangiogenesis in Overdrive: Inflammation and Cancer
7:30 pm - 7:40 pm
"Studying the Mechanisms that Prepare the Developing Lung for Inflation at Birth"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"A Novel Biogenic Amine Released by Lymphatic Endothelial Cells Restrains Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"A Precision Medicine Approach to Understanding Congenital Lymphatic Anomalies"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"The Natural Product Iripallidal Promotes Lymphangiogenesis in Response to Injury via RASGRP3"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"RASA1-Mediated Control of Lymphatic and Blood Vascular Development and Function"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"MHC Class II Expression by Tumoral Lymphatics Is Required for Tumor Specific Signature and Suppressive Functions of Treg Cells"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Lymphatic Vessel Heterogeneity in the Era of Single Cell Analysis
9:00 am - 9:20 am
"Reprogramming of the Liver Lymphatic Endothelium During Chronic Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Zebrafish Lymphatic Endothelial Cell Specification at Single Cell Resolution"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Single-Cell Transcriptional Cross-Mapping of the Mouse and Human Lymph Node Lymphatic Vasculature"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Novel Insights into Lymphatic Development from the Zebrafish"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Foxc Transcription Factors in Organ-Specific Lymphatic Function"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Piezo1-Mediated Activation of Lymphatic Function and Growth"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Identifying Novel Modifier Genes Related to Naturally-Occurring Heterogeneity of Lymphatics Within a Diverse Genetic Population"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Engineering and Therapeutics for the Lymphatic System
7:30 pm - 7:50 pm
"Targeting the Mesenteric Lymph Using Triglyceride-Mimetic Prodrugs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lymphatic Tissue Engineering"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Fate Mechanisms that Drive Lymphangiogenesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Engineering Biomaterials for Lymphatic Morphogenesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Theralymph: An Innovative H2020 Program to Perform Gene Therapy for Lymphedema"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure