The Microbial Toxins and Pathogenicity Gordon Conference is an exceptional forum for learning about the newest knowledge in the field of microbial pathogenesis. The focus is on basic mechanisms, primarily from bacterial systems that exemplify common themes in toxin biochemistry and biogenesis, molecular and cellular pathogenesis, and infection and immunity. New research on translating knowledge of basic mechanisms into therapeutic advances will also be presented. Speakers include established leaders in the field as well as young investigators of exceptional promise. Sessions are chaired by prominent researchers who broadly review the topic and place the speakers' work into that context. Discussions led by the session chair are lively exchanges of new ideas and perspectives stimulated by each talk. In addition to the main sessions, this meeting includes well-attended and highly interactive poster sessions. In 2008, the main conference will be preceded by the Gordon Research Seminar on Microbial Toxins and Pathogenicity. This weekend meeting, planned by and for post-doctoral and pre-doctoral trainees in the field of microbial pathogenesis, will provide an opportunity for future leaders in the field to present their work as talks and posters in a collegial and interactive environment. Attendance at the GRS will add great value to the overall GRC experience for these young investigators.