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Cell Biology of Megakaryocytes and Platelets (GRS)
Gordon Research Seminar

The Extraordinary Journey from Stem Cell to Platelet: Roles in Hemostasis and Beyond

Dates

February 25-26, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Natalie S. Poulter & Sarah J. Fletcher

Meeting Description

The Gordon Research Seminar on Cell Biology of Megakaryocytes and Platelets is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to bring together our understanding of the processes involved in the development of the megakaryocyte and platelet cell lineage and how these cells can contribute to health and disease. This GRS meeting will provide young investigators a unique platform for presentation and active discussion of their latest and most innovative work. Researchers will be encouraged to discuss ongoing challenges and to develop an extensive network to establish future collaborations between the fields of megakaryocyte and platelet biology. Through career-oriented presentations and round table discussions, this GRS will also provide young investigators with valuable career advice from experts who conduct basic and translational research both within and outside of academia.

Related Meeting

This GRS was held in conjunction with the "Cell Biology of Megakaryocytes and Platelets" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: From Basic Biology to Novel Therapies
Discussion Leader: Natalie Poulter (University of Birmingham, United Kingdom)
3:15 pm - 3:45 pmMartine Jandrot-Perrus (Laboratory for Vascular Translational Science (LVTS), Paris Diderot University, France)
"From Basic Biology to Novel Therapies"
3:45 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMegakaryocyte and Platelet Signalling and Development
Discussion Leaders: Alex Bye (University of Reading, United Kingdom) and Benjamin Tourdot (University of Michigan, USA)
5:30 pm - 5:45 pmVanessa Scanlon (Yale University, USA)
"Developing Live Imaging Strategies to Analyze MEP Fate Decisions at the Single Cell Level"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmVeronica Palma Barqueros (Hospital General Universitario Morales Meseguer, Spain)
"Role of Immunoreceptor Tyrosine-Based Activation/Inhibition Motif (ITAM/ITIM)-Containing Receptors in Neonatal Platelet Reactivity"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmSamantha Moore (University of Bristol, United Kingdom)
"Phosphorylation of GSK-3 Alpha Restrains GPVI-Mediated Platelet Function"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmChiara Pallini (College of Medical and Dental Sciences, University of Birmingham, United Kingdom)
"Investigating Collagen Receptor Organization and Signalling in Platelets Using Super Resolution Microscopy and Cluster Analysis"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmJoanne Dunster (University of Reading, United Kingdom)
"The Importance of Regulation in GPVI Signal Transduction: A Systems Biology Approach"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmAlex Slater (University of Nottingham, United Kingdom)
"Complement Receptor gC1qR Interaction with Coagulation Factor XII and Kininogen"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMegakaryocytes and Platelets in Health and Disease
Discussion Leaders: Amanda Dalby (University of Cambridge, United Kingdom) and Marie-Blanche Onselaer (University of Birmingham, United Kingdom)
9:00 am - 9:15 amBelinda Guo (University of Western Australia, Australia)
"Platelet Transcriptome Provides a Unique Insight on the Status of Bone Marrow Fibrosis in Patients with Myeloproliferative Neoplasms"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMarten Hansen (Sanquin, The Netherlands)
"GFI1B Regulates Megakaryocyte Development Through LSD1 Interaction"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAbdullah Khan (University of Birmingham, United Kingdom)
"CRISPR-Cas9 Mediated Labelling of Genes Implicated in Thrombocytopenia for Super-Resolution Microscopy"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amAndreas Wersall (University of Bristol, United Kingdom)
"Deletion of Ral GTPases in Mouse Platelets Reveals a Major Role in Regulation of a -Granule P-Selectin Exposure, but Not in the Release of a -Granule Content"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amAmanda Unsworth (University of Reading, United Kingdom)
"Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amPierre Cunin (Brigham and Women's Hospital, USA)
"Emperipolesis Is a Novel Cell-in-Cell Phenomenon that Mediates Transfer of Neutrophil Membrane to Megakaryocytes and Platelets"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Careers in Academia and Beyond
Discussion Leaders: Benjamin Kile (Walter and Eliza Hall Institute of Medical Research, Australia) and Wolfgang Bergmeier (University of North Carolina at Chapel Hill, USA)
1:30 pm - 1:45 pmNicola Mutch (University of Aberdeen, United Kingdom)
"Balancing Life with Haemostasis"
1:45 pm - 2:00 pmDiscussion
2:00 pm - 2:15 pmJonathan Thon (Brigham and Women's Hospital, USA)
"Combining Academia and Industry: My Experience"
2:15 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL135868-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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