Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						 
						 
					
						
						
7:40 pm - 9:30 pm 
	
New Takes on Transport Along the Secretory Pathway 
 
 
 
						 
						 
					
						
						
7:40 pm - 8:05 pm 
	
"Kinetic Mapping of the Secretory Pathway" 
 
 
 
						 
						 
					
						
						
8:05 pm - 8:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:10 pm - 8:35 pm 
	
"Cytoskeletal Fences and Transmembrane Pickets: Diffusional Barriers at the Plasma Membrane" 
 
 
 
						 
						 
					
						
						
8:35 pm - 8:40 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:40 pm - 9:05 pm 
	
"The Genetic Architecture of Insulin Secretion" 
 
 
 
						 
						 
					
						
						
9:05 pm - 9:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:10 pm - 9:25 pm 
	
"Cellular Calcium Stress Induces Golgi Fragmentation Through PKCa Activation" 
 
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Endocytic Pathway Trafficking and Connections to the Secretory Pathway 
 
 
 
						 
						 
					
						
						
9:00 am - 9:25 am 
	
"Sorting of Endolysosomal Proteins at the Golgi Complex" 
 
 
 
						 
						 
					
						
						
9:25 am - 9:30 am 
	
Discussion
 
 
						 
						 
					
						
						
9:30 am - 9:55 am 
	
"Multiple Roles of CORVET and HOPS Tethering Proteins in Membrane Trafficking" 
 
 
 
						 
						 
					
						
						
9:55 am - 10:00 am 
	
Discussion
 
 
						 
						 
					
						
						
10:00 am - 10:15 am 
	
"GPP130 and CASC4 Are Novel Substrates of PC7 and Furin: Investigating Their Roles in Cancer Progression" 
 
 
 
						 
						 
					
						
						
10:15 am - 10:20 am 
	
Discussion
 
 
						 
						 
					
						
						
10:20 am - 10:30 am 
	
"Dense-Core Granule Biogenesis in Drosophila  Secondary Cells Requires Cross-Talk Between the Secretory and Endosomal Pathways and a Rab6 to Rab11 Transition" 
 
 
 
						 
						 
					
						
						
10:30 am - 10:35 am 
	
Discussion
 
 
						 
						 
					
						
						
10:35 am - 11:05 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:05 am - 11:30 am 
	
"Golgi Response to Cellular Stress" 
 
 
 
						 
						 
					
						
						
11:30 am - 11:35 am 
	
Discussion
 
 
						 
						 
					
						
						
11:35 am - 12:00 pm 
	
"Live Imaging of Proprotein Convertase Activities at Subcellular Resolution" 
 
 
 
						 
						 
					
						
						
12:00 pm - 12:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:05 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Updates on Processing (and Beyond) in the Secretory and Endocytic Pathways 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:55 pm 
	
"PCSK1 and proSAAS in Human Disease" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:00 pm - 8:25 pm 
	
"Lessons on the Role of POMC Derived Peptides in Obesity from Man's Best Friend" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 8:55 pm 
	
"The Non-Enzymatic Functions of the Proprotein Convertases: PCSK9 and PCSK7 and Their Relationship to Dyslipidemia" 
 
 
 
						 
						 
					
						
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:00 pm - 9:25 pm 
	
"D-Amino Acid Containing Neuropeptides" 
 
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Novel Treatment Mechanisms Targeting Diabetes, Obesity, Metabolic Syndrome et al . 
 
 
 
						 
						 
					
						
						
9:00 am - 9:25 am 
	
"Amplifying Insulin Secretion in β-Cells" 
 
 
 
						 
						 
					
						
						
9:25 am - 9:30 am 
	
Discussion
 
 
						 
						 
					
						
						
9:30 am - 9:55 am 
	
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists" 
 
 
 
						 
						 
					
						
						
9:55 am - 10:00 am 
	
Discussion
 
 
						 
						 
					
						
						
10:00 am - 10:10 am 
	
"Beta Cell Loss of Prohormone Convertase 1/3 or Carboxypeptidase E Does Not Impair Glycemic Control" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:15 am 
	
Discussion
 
 
						 
						 
					
						
						
10:15 am - 10:25 am 
	
"Domains Responsible for trans -Golgi Network Targeting of the Peripheral Membrane Protein HID-1" 
 
 
 
						 
						 
					
						
						
10:25 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Group Photo / Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:25 am 
	
"Novel Unimolecular Multiagonists for the Treatment of Obesity and Diabetes" 
 
 
 
						 
						 
					
						
						
11:25 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 11:55 am 
	
"Targeting Pancreatic Cancer by Conformational Selective Anti-MMP7 Inhibitory Antibody" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:25 pm 
	
"Dissecting DDX3X Nuclear Export to Unlock Novel Anti-Viral Therapeutic Approaches" 
 
 
 
						 
						 
					
						
						
12:25 pm - 12:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Significance of Intra-Membrane Proteolysis and Proteolytic Events at the Cell Surface 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:55 pm 
	
"A Single-Molecule View of Rhomboid Protease Function Inside the Cell Membrane" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:00 pm - 8:25 pm 
	
"iRhoms: Key Regulators of ADAM17-Dependent TNF and EGFR Signaling" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 8:50 pm 
	
"The Intramembrane Protease SPPL2c Is Critical for Male Germ Cell Development by Processing Selected Tail-Anchored Proteins" 
 
 
 
						 
						 
					
						
						
8:50 pm - 8:55 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:55 pm - 9:10 pm 
	
"Substrates and Functions of ADAM10 in the Mammalian Nervous System" 
 
 
 
						 
						 
					
						
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:15 pm - 9:25 pm 
	
"The Secreted Metalloproteases ADAMTS9 and ADAMTS20 Have a Dual Role in Ciliogenesis and Extracellular Matrix Proteolysis" 
 
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Protein Processing in Development, Reproduction and Ageing 
 
 
 
						 
						 
					
						
						
9:00 am - 9:25 am 
	
"Control of Proteolysis in Drosophila  Terminal Patterning" 
 
 
 
						 
						 
					
						
						
9:25 am - 9:30 am 
	
Discussion
 
 
						 
						 
					
						
						
9:30 am - 9:55 am 
	
"Regulation of BMP Homo- and Heterodimer Activity by Prodomains and Interactions with the ECM" 
 
 
 
						 
						 
					
						
						
9:55 am - 10:00 am 
	
Discussion
 
 
						 
						 
					
						
						
10:00 am - 10:25 am 
	
"Can the Sex Life of Drosophila  Tell Us Anything About the Processing of Invadolysin?" 
 
 
 
						 
						 
					
						
						
10:25 am - 10:30 am 
	
Discussion
 
 
						 
						 
					
						
						
10:30 am - 11:00 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:00 am - 11:25 am 
	
"Mitonuclear Communication in Response to Nutrient Stress" 
 
 
 
						 
						 
					
						
						
11:25 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 11:40 am 
	
"An Independent Role of the Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability" 
 
 
 
						 
						 
					
						
						
11:40 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 11:55 am 
	
"The Role of Furin in Obesity and Type 2 Diabetes" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Secretory Proteases and Inhibitors in Health and Disease 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:55 pm 
	
"The Protease ADAM17 Drives Inflammation and Cancer" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:00 pm - 8:25 pm 
	
"KLK Peptidases as Secreted Mediators of Invasive Processes in Prostate and Ovarian Cancer" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 8:55 pm 
	
"An Inside-out Role for Cathepsin B in Cancer" 
 
 
 
						 
						 
					
						
						
8:55 pm - 9:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:00 pm - 9:10 pm 
	
"The KDEL Receptors Regulate Secretion of Endoplasmic Reticulum Resident Proteins Under Endoplasmic Reticulum Stress" 
 
 
 
						 
						 
					
						
						
9:10 pm - 9:15 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:15 pm - 9:25 pm 
	
"Neuropeptide Processing Proteases in Health and Disease: A Role for Endothelin Converting Enzyme in Modulating Pain" 
 
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Challenges in Protein Processing and Secretion 
 
 
 
						 
						 
					
						
						
9:00 am - 9:15 am 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
9:15 am - 9:40 am 
	
"The Marriage of Experiment and Theory in Investigating the Molecular Mechanisms of Action of Proteases and Their Inhibitors" 
 
 
 
						 
						 
					
						
						
9:40 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:10 am 
	
"GPR3 and Novel GPCR Signaling in Alzheimer's Disease" 
 
 
 
						 
						 
					
						
						
10:10 am - 10:15 am 
	
Discussion
 
 
						 
						 
					
						
						
10:15 am - 10:30 am 
	
"Cell-Associated, Heparin-Like Molecules Modulate the Ability of LDL to Regulate PCSK9 Uptake" 
 
 
 
						 
						 
					
						
						
10:30 am - 10:35 am 
	
Discussion
 
 
						 
						 
					
						
						
10:35 am - 11:05 am 
	
Coffee Break
 
 
						 
						 
					
						
						
11:05 am - 11:20 am 
	
"Chromogranin A, the Major Lumenal Protein in Chromaffin Granules, Controls Fusion Pore Expansion and Its Expression in Granules Is Regulated" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:25 am 
	
Discussion
 
 
						 
						 
					
						
						
11:25 am - 11:35 am 
	
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting" 
 
 
 
						 
						 
					
						
						
11:35 am - 11:40 am 
	
Discussion
 
 
						 
						 
					
						
						
11:40 am - 11:55 am 
	
"Sorting of a Multi-Subunit Ubiquitin Ligase Complex in the Endolysosome System" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:15 pm 
	
"Modular Lipid Binding by Yeast Vps13p Can Promote Apposition of Bilayers with Distinct Lipid Compositions" 
 
 
 
						 
						 
					
						
						
12:15 pm - 12:20 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:20 pm - 12:30 pm 
	
General Discussion: Therapeutic Options and Outcome Studies: From Cell Biology and Genetics to Future Perspectives
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Mechanisms and Approaches in Protein Processing and Sorting in Signaling 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:55 pm 
	
"Development of a nM Molecular Corrector Specifically Rescuing MALT1 Activity in NFkB Signalling in Immunodeficency" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:00 pm - 8:25 pm 
	
"Regulation of Prolonged GPCR Signaling that Creates Sequential Neuronal Activation Within Circadian Pacemaker Circuit" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:30 pm - 8:45 pm 
	
"Sphingolipid Metabolism Impinges on Calcium-Dependent Sorting of Secretory Cargo in the trans -Golgi Network" 
 
 
 
						 
						 
					
						
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:00 pm 
	
"Analysis of Protein Sorting at the trans -Golgi Network Through STORM Super-Resolution Imaging" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:05 pm - 9:20 pm 
	
"Multifaceted Regulation of Exocytosis by Synaptotagmin-7" 
 
 
 
						 
						 
					
						
						
9:20 pm - 9:25 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:25 pm - 9:30 pm 
	
Closing Remarks
 
 
						 
						 
					
						
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am 
	
Departure