Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Takes on Transport Along the Secretory Pathway
7:40 pm - 8:05 pm
"Kinetic Mapping of the Secretory Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Cytoskeletal Fences and Transmembrane Pickets: Diffusional Barriers at the Plasma Membrane"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Genetic Architecture of Insulin Secretion"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Cellular Calcium Stress Induces Golgi Fragmentation Through PKCa Activation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endocytic Pathway Trafficking and Connections to the Secretory Pathway
9:00 am - 9:25 am
"Sorting of Endolysosomal Proteins at the Golgi Complex"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Multiple Roles of CORVET and HOPS Tethering Proteins in Membrane Trafficking"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"GPP130 and CASC4 Are Novel Substrates of PC7 and Furin: Investigating Their Roles in Cancer Progression"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Dense-Core Granule Biogenesis in Drosophila Secondary Cells Requires Cross-Talk Between the Secretory and Endosomal Pathways and a Rab6 to Rab11 Transition"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Golgi Response to Cellular Stress"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Live Imaging of Proprotein Convertase Activities at Subcellular Resolution"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Updates on Processing (and Beyond) in the Secretory and Endocytic Pathways
7:30 pm - 7:55 pm
"PCSK1 and proSAAS in Human Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Lessons on the Role of POMC Derived Peptides in Obesity from Man's Best Friend"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Non-Enzymatic Functions of the Proprotein Convertases: PCSK9 and PCSK7 and Their Relationship to Dyslipidemia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"D-Amino Acid Containing Neuropeptides"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Treatment Mechanisms Targeting Diabetes, Obesity, Metabolic Syndrome et al .
9:00 am - 9:25 am
"Amplifying Insulin Secretion in β-Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Beta Cell Loss of Prohormone Convertase 1/3 or Carboxypeptidase E Does Not Impair Glycemic Control"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Domains Responsible for trans -Golgi Network Targeting of the Peripheral Membrane Protein HID-1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
"Novel Unimolecular Multiagonists for the Treatment of Obesity and Diabetes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Targeting Pancreatic Cancer by Conformational Selective Anti-MMP7 Inhibitory Antibody"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Dissecting DDX3X Nuclear Export to Unlock Novel Anti-Viral Therapeutic Approaches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Significance of Intra-Membrane Proteolysis and Proteolytic Events at the Cell Surface
7:30 pm - 7:55 pm
"A Single-Molecule View of Rhomboid Protease Function Inside the Cell Membrane"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"iRhoms: Key Regulators of ADAM17-Dependent TNF and EGFR Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Intramembrane Protease SPPL2c Is Critical for Male Germ Cell Development by Processing Selected Tail-Anchored Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Substrates and Functions of ADAM10 in the Mammalian Nervous System"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"The Secreted Metalloproteases ADAMTS9 and ADAMTS20 Have a Dual Role in Ciliogenesis and Extracellular Matrix Proteolysis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Processing in Development, Reproduction and Ageing
9:00 am - 9:25 am
"Control of Proteolysis in Drosophila Terminal Patterning"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of BMP Homo- and Heterodimer Activity by Prodomains and Interactions with the ECM"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Can the Sex Life of Drosophila Tell Us Anything About the Processing of Invadolysin?"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mitonuclear Communication in Response to Nutrient Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"An Independent Role of the Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Role of Furin in Obesity and Type 2 Diabetes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Secretory Proteases and Inhibitors in Health and Disease
7:30 pm - 7:55 pm
"The Protease ADAM17 Drives Inflammation and Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"KLK Peptidases as Secreted Mediators of Invasive Processes in Prostate and Ovarian Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"An Inside-out Role for Cathepsin B in Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The KDEL Receptors Regulate Secretion of Endoplasmic Reticulum Resident Proteins Under Endoplasmic Reticulum Stress"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Neuropeptide Processing Proteases in Health and Disease: A Role for Endothelin Converting Enzyme in Modulating Pain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Challenges in Protein Processing and Secretion
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"The Marriage of Experiment and Theory in Investigating the Molecular Mechanisms of Action of Proteases and Their Inhibitors"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
"GPR3 and Novel GPCR Signaling in Alzheimer's Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Cell-Associated, Heparin-Like Molecules Modulate the Ability of LDL to Regulate PCSK9 Uptake"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"Chromogranin A, the Major Lumenal Protein in Chromaffin Granules, Controls Fusion Pore Expansion and Its Expression in Granules Is Regulated"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Sorting of a Multi-Subunit Ubiquitin Ligase Complex in the Endolysosome System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Modular Lipid Binding by Yeast Vps13p Can Promote Apposition of Bilayers with Distinct Lipid Compositions"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion: Therapeutic Options and Outcome Studies: From Cell Biology and Genetics to Future Perspectives
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms and Approaches in Protein Processing and Sorting in Signaling
7:30 pm - 7:55 pm
"Development of a nM Molecular Corrector Specifically Rescuing MALT1 Activity in NFkB Signalling in Immunodeficency"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Regulation of Prolonged GPCR Signaling that Creates Sequential Neuronal Activation Within Circadian Pacemaker Circuit"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Sphingolipid Metabolism Impinges on Calcium-Dependent Sorting of Secretory Cargo in the trans -Golgi Network"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Analysis of Protein Sorting at the trans -Golgi Network Through STORM Super-Resolution Imaging"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Multifaceted Regulation of Exocytosis by Synaptotagmin-7"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure