Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Life at a Higher Resolution
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Selected New Directions with Single Molecules: Methods and Biological Insights"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Unraveling the Spatial and Temporal Dynamics of Subcellular Organelles"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single-Molecule Approaches in Chemistry
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Towards Predictive Separations One Protein at a Time"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Accessing Single-Molecule Chemical Dynamics Using Optical Microresonators"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Lost and Bound Between the Basepairs: Hyperstretched and Tilted States"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Organic Chemistry and Molecular Catalysts: Imaging Mechanisms at Single Particles and Molecules"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Single-Molecule Probes and Single Particles, Probed: Approaches to Studying Complex Chemical Systems"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Fundamental Cellular Processes
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
"The Enzyme Catalysis Problem"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
"Towards Optimal Imaging of Single-Molecule Rotational Dynamics at the Nanoscale"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"From Single Molecule to Single Cells: Imaging Fundamental Nucleic Acid Enzymes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"4D Characterization of Spatiofunctional Enzyme Assemblies in Living Cells"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"The Mechanism of Dynein's Force Generation and Unidirectional Motility"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Photosynthesis and Energy Transfer
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Why Don't Plants Get Sunburn?"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Spatially-Resolved Fluorescence-Detected Two-Dimensional Electronic Spectroscopy for In Vivo Studies of Photosynthetic Bacteria"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Inspired by Nature: Energy Transport in Artificial Supramolecular Structures"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Measuring Charge Transport Through Single Molecules"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"The Quantum Design of Photosynthesis"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Photophysical Heterogeneity of Single Phycobilisomes Quenched by the Orange Carotenoid Protein"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Single Molecule Measurements of Substrate Transport by a Primary Active Proton Pumping ATPase"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single Molecules in Living Cells
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Comparing Kinesin and Dynein Motors During Axonal Transport"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Illuminating the Biochemical Activity Architecture of the Cell"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Expansion STORM Enables Imaging Beyond the Superresolution Limit"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Using Single-Molecule Tracking to Dissect the Cytoskeletal and Enzymatic Machines that Grow and Divide Bacteria"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Localization Microscopy: Advances in Methodology for Biological Applications"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Probing the Chromatin Structural Basis of DNA Replication Activation in Mammalian Cells"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Spatial Transcriptomics Through Single-Molecule Imaging"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Multi-Dimensional Super-Resolution Microscopy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Smart Super-Resolution Microscopy for Multi-Color 3D Reconstruction"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single-Molecule Nanophotonics and Plasmonics
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Exploring Dynamical Heterogeneity with Single Molecules and Single Gold Nanoparticles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Super-Resolution Imaging of Plasmonic Nanostructures"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Magnetometry at the Single-Molecule Length Scale"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Single-Molecule Femto-Second Spectroscopy and Nanocavity Coupling"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Single-Molecule Mechanics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"What's Right, and What's Wrong, with the Kinesin Mechanochemical Cycle"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Single-Molecule Electrometry: Visualizing Molecular Electrostatics and 3D Conformation in an Optical Microscope"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Protamine Folds DNA Before Forming Loops"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Probing Biomolecular Interactions with Parallel Force Spectroscopy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Visualizing Structure-Mediated Interactions in Supercoiled DNA Molecules"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Characterizing Complex Phenotypes of a Library of Cells at Single Molecule Sensitivity"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Single Molecules to Complex Systems
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Supramolecular Signatures of Broken Detailed Balance in Living Systems"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Single-Molecule Imaging of Pores in Lipid Membranes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Single-Molecule Biology: When Stochasticity Meets Precision"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure