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Single Molecule Approaches to Biology

Gordon Research Conference

Bridging Scales and Disciplines: The Multifaceted Landscape of Single-Molecule Biology

June 28 - July 3, 2026

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

and

Vice Chairs

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Les Diablerets Conference Center

Eurotel Victoria

Les Diablerets, Vaud (fr), Switzerland

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by May 31, 2026. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Single Molecule Approaches to Biology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

A distinctive feature of the international single-molecule field is its interdisciplinarity, bridging physics, biology, and chemistry, and engaging experimentalists, theorists, and computational scientists. The 2026 Gordon Conference on Single Molecule Approaches to Biology aims to bring together experts and trainees from across the full spectrum of the field, covering techniques such as fluorescence and force spectroscopies, nanopores, microfluidics, light scattering, molecular trapping, super-resolution and high-speed AFM imaging, enabling chemistries and (bio-)nano-fabrication, theory, simulations, and integrative approaches, among others. By bringing together those developing novel single-molecule technologies and those advancing our mechanistic understanding of biological systems, this conference aims to accelerate the next wave of breakthroughs as the field matures and evolves.

Related Meeting

This GRC will be held in conjunction with the "Single Molecule Approaches to Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Chromatin Through Cellular Architecture Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:30 pm	"Single-Molecule Nanotechnology for Biology: From Chromosome Motors to Protein Sequencing to Building a Synthetic Cell"
8:30 pm - 8:45 pm	Discussion
8:45 pm - 9:15 pm	"Super-Resolution Imaging of Chromatin in Health and Disease"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	New Sensing Modalities for Single-Molecule Studies Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Label-Free Profiling of Solution-Phase Molecules"
9:35 am - 9:50 am	Discussion
9:50 am - 10:15 am	"Functional Single-Molecule Bond-Selective Microscopy"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Angstrom Precision in Cryogenic Localization Microscopy of Proteins in the Native Cell Membrane"
11:55 am - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Group Photo / Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Engineering Molecules: Novel Sensors and de Novo Protein Design Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:35 pm	"Designing Dynamics into Proteins"
6:35 pm - 6:50 pm	Discussion
6:50 pm - 7:00 pm	Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm	Discussion
7:05 pm - 7:15 pm	Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:45 pm	"Design Principles of Protein Mechanostability"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Spatio-Temporal Resolution of Conformational Dynamics Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Observing Protein Dynamics with Microsecond Time-Resolved Cryo-EM"
9:35 am - 9:50 am	Discussion
9:50 am - 10:00 am	Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am	Discussion
10:05 am - 10:15 am	Short Talk Selected from Poster Abstracts
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:15 am	"Enhancer-Promoter Dynamics in Chromatin"
11:15 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Structural Dynamics of mRNA Recruitment to the Eukaryotic Ribosome"
11:55 am - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Single Molecule Tools to Decode Cell Biology Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:35 pm	"Multidimensional Single-Molecule Imaging: Linking Rotational Dynamics to Biological Function"
6:35 pm - 6:50 pm	Discussion
6:50 pm - 7:00 pm	Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm	Discussion
7:05 pm - 7:15 pm	Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:45 pm	"Resolving Protein Organization in Cells with Nanometer Resolution"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Nanotechnology and Single-Molecule Studies: A Synergistic Approach Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Nanomechanical Systems for Single-Molecule Biophysics"
9:30 am - 9:45 am	Discussion
9:45 am - 9:55 am	Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Opening the Black Box - Operando Microscopy of Protein Pores"
11:10 am - 11:25 am	Discussion
11:25 am - 11:35 am	Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am	Discussion
11:40 am - 12:05 pm	"Windows and Handles for Nanoscale Biophysics"
12:05 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Spectroscopic Observation of Molecular Behavior Discussion Leader:
6:00 pm - 6:10 pm	Introduction by Discussion Leader
6:10 pm - 6:35 pm	"From Method to Mechanisms: SLAM-FRET Enables Single-Molecule Analysis of Dynamic Human RNA Machineries"
6:35 pm - 6:50 pm	Discussion
6:50 pm - 7:00 pm	Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm	Discussion
7:05 pm - 7:15 pm	Short Talk Selected from Poster Abstracts
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:45 pm	"Dynamic Control of Chromatin Architecture and DNA Resolution"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Single-Molecule Proteomics Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Molecular Stereometry: The Narrow-Escape Problem Meets Structural Biology"
9:30 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Towards Mechanostructural Proteomics with High-throughput DNA Nanoswitch Calipers"
10:10 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Single-Molecule Nanopores Proteomics"
11:20 am - 11:35 am	Discussion
11:35 am - 11:45 am	Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am	Discussion
11:50 am - 12:15 pm	"Nanopores and Nanofluidics for Label and Label Free Single-Molecule Biosensing"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Keynote Session: Dynamics Detection with Light and Pores Discussion Leader:
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:35 pm	"Nanopore Multiomics"
6:35 pm - 6:50 pm	Discussion
6:50 pm - 7:35 pm	"Parallel Stopped-Flow Interrogation of Diverse Biological Systems at the Single-Molecule Scale"
7:35 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Single Molecule Approaches to Biology (GRS) Contribute Financially to This Conference

Conference Fees

Similar Conferences

Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$2,045.00

Conferee Shared Room:

$1,725.00

Conferee Off-Site:

$1,470.00

Guest Single Room:

$1,825.00

Guest Shared Room:

$1,505.00

Guest Off-Site:

$1,250.00

Child 4-12 yrs Shared Room:

$753.00

Child 4-12 yrs Off-Site:

$625.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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