| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Welcome / Introductory Comments |
| 7:45 pm - 9:30 pm | THIOL-BASED REDOX SYSTEMS |
| Discussion Leader: Vadim Gladyshev (U Nebraska) |
| 7:45 pm - 8:25 pm | Jon Beckwith (Harvard)
"Folding and Misfolding of Disulfide-bonded Proteins" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Arne Holmgren (Karolinska)
"Thioredoxin and Glutaredoxin: Revisiting DNA Synthesis and Redox Signaling" |
| 9:15 pm - 9:25 pm | Discussion |
| 9:30 pm | Welcome Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | THE THIOREDOXIN AND GLUTATHIONE SYSTEMS |
| Discussion Leader: John Mieyal (Case Western Reserve University) |
| 9:00 am - 9:30 am | Bob Buchanan (University of California, Berkeley)
"The Horizon of Redox Regulation Continues to Broaden in Plants" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Joseph Loscalzo (Boston University)
"Redox Determinants and Regulatory Functions of the Thiol Proteome" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee/Tea Break |
| 10:50 am - 11:15 am | Short Selected Talk: Mark Hampton (Christchurch School of Medicine, New Zealand)
"Peroxiredoxin 3 and the Redox Regulation of Apoptosis" |
| 11:15 am - 11:40 am | Short Selected Talk: W. Todd Lowther (Wake Forest)
"Novel Features of the Sulfiredoxin-Peroxiredoxin Embrace in Recognition and Catalysis" |
| 11:40 am - 12:05 pm | Short Selected Talk: Adam Benham (University of Durham, UK)
"PDILT, an Unconventional PDI Homolog of the Testis" |
| 12:05 pm - 12:30 pm | Short Selected Talk: Jakob Winther (Institute of Molecular Biology and Physiology, Denmark)
"A Yellow Fluorescent Protein-Based Indicator of Thiol-Disulfide Reactions" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (A-L) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DISULFIDE BOND FORMATION AND ISOMERIZATION |
| Discussion Leader: Colin Thorpe (U Delaware) |
| 7:30 pm - 8:00 pm | James Bardwell (HHMI/U Michigan)
"Laboratory Evolution of Disulfide Catalysts" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Roberto Sitia (Universita Vita-Salute San Raffaele, Milan)
"Redox Control in the Endoplasmic Reticulum" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Hiram Gilbert (Baylor)
"Disulfide Formation and Isomerization During Protein Folding in the Endoplasmic Reticulum" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | REDOX REGULATION AND DISEASE |
| Discussion Leader: Leonore Herzenberg (Stanford) |
| 9:00 am - 9:30 am | Nick Tonks (CSHL)
"Redox Regulation of Protein Tyrosine Phosphatases" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Peter Cresswell (HHMI/Yale)
"Thiol Oxidoreductases in Antigen Processing" |
| 10:10 am - 10:20 am | Discussion |
| 10:25 am - 10:45 am | Coffee/Tea Break |
| 10:45 am - 11:15 am | Leonard Herzenberg (Stanford)
"High Dose Oral N-Acetylcysteine Reduces Lung Inflammation in Cystic Fibrosis" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Ruma Banerjee (U. Nebraska)
"Homocysteine and Modulation of Redox Capacity" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:30 pm | Short Selected Talk: Abraham Brown (Burke/Cornell Medical College)
"The Impact of Zinc on Mitochondrial Thiol Redox Enzymes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (A-L) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MECHANISMS OF REDOX SIGNALING AND REGULATION |
| Discussion Leader: Carla Koehler (UCLA) |
| 7:30 pm - 8:00 pm | Michel Toledano (SBGM, DBJC, CEA-Saclay, France)
"H2O2 Signaling by Cysteine Redox Modifications" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Sue Goo Rhee (NIH)
"Regulation of Peroxiredoxin Activity Via Sulfinylation and Phosphorylation" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Brian Morgan (University of Newcastle upon Tyne)
"Regulation of Cellular Responses to Hydrogen Peroxide" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SELENIUM AND SULFUR IN REDOX BIOLOGY |
| Discussion Leader: Gary Merrill (Oregon State U) |
| 9:00 am - 9:30 am | Dolph Hatfield (NCI, NIH)
"How Selenium has Altered our Understanding of the Genetic Code and Thiol-dependent Processes" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Elias Arner (Karolinska)
"The Selenocysteine Residue in Thioredoxin Reductase as a Key Target for Electrophilic Anticancer Drugs" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Coffee/Tea Break |
| 10:35 am - 11:05 am | Frank Fitzpatrick (University of Utah)
"Lipid Dioxygenases and Cellular Redox Signaling" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Short Selected Talk: Jin Xu (Wyeth Biopharma)
"The Role of Disulfide Bond Shuffling in GPG-290 Aggregation" |
| 11:40 am - 12:05 pm | Short Selected Talk: Agnieszka Chacinska (University of Freiburg, Germany)
"The Role of Thiol-Disulfide Exchange in the Biogenesis of Mitochondria" |
| 12:05 pm - 12:30 pm | Short Selected Talk: David Williams (Illinois State University)
"Thiol-based Redox Enzymes as Novel Drug Targets for Schistosomiasis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (M-Z) |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | REDOX HOMEOSTASIS AND REGULATION |
| Discussion Leader: Kostas Tokatlidis (IMBB-FORTH, Greece) |
| 7:30 pm - 8:00 pm | Toren Finkel (NHLBI/NIH)
"Signaling by Oxygen Radicals" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Johannes Herrmann (U. Munich)
"The Disulfide Relay System of the Mitochondrial Intermembrane Space" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jonathan Stamler (HHMI/Duke)
"Protein S-nitrosylation Updated" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | APPLICATIONS OF BIOINFORMATICS, GENOMIC AND PROTEOMICS IN REDOX BIOLOGY |
| Discussion Leader: Jacquelyn Fetrow (Wake Forest) |
| 9:00 am - 9:30 am | Todd Yeates (UCLA)
"Discovery of a Novel Mechanism for Thermostability: Disulfide bonds that tie up proteins in links and knots" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Pietro Ghezzi (Mario Negri Institute, Milan)
"Redox Regulation Through Protein Glutathionylation" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee/Tea Break |
| 10:45 am - 11:15 am | Patricia Babbitt (UCSF)
"An Evolutionary Blueprint for Divergence of Flavin-mediated Catalysis" |
| 11:15 am - 11:25 am | Discussion |
| 11:25 am - 11:55 am | Ursula Jakob (U. Michigan)
"A Snapshot of in vivo Thiol Modification" |
| 11:55 am - 12:05 pm | Discussion |
| 12:05 pm - 12:30 pm | Short Selected Talk: Jennifer Martin (University of Queensland, Australia)
"One Disulfide or Two: Sequence, Structure and Function of Divergent and Hybrid DsbAs" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (M-Z) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MECHANISMS OF THIOL-BASED CATALYSIS |
| Discussion Leader: D. James Morre (Purdue) |
| 7:30 pm - 8:00 pm | Colin Thorpe (University of Delaware)
"Thiols and Flavins: Mechanisms of Oxidative Protein Folding from Pox Virus to Human Growth Factors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Joris Messens (Vrije Universiteit, Brussels)
"Thiol-based Catalysis Mechanisms for the Reduction of Arsenate" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Leslie Poole (Wake Forest)
"Cysteine Sulfenic Acids in Catalysis and Regulation" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Mixer |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
