Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Concepts and Directions in Redox Signaling Research
7:40 pm - 8:20 pm
"Redox Signaling Meets Aging Biology"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Functional Genomic Screens to Uncover Redox Biology"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Tools for Redox Signaling Research
9:00 am - 9:20 am
"Fluorescent Protein Based Biosensors for Compartmentalized Redox Parameters"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Genetically Encoded Sensors for Visualizing Redox Metabolism in Living Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Direct Mapping of oxiPTMs in Proteomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Understanding and Monitoring the Action of Redox-Directed Cancer Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Swiss Army Man: A Single Molecule that Simultaneously Profiles and Decodes Precision Protein-Cysteine Signaling Axes in Living Systems"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Genetically Encoded Tools for Compartment-Specific Manipulation of NAD+/NADH and NADP+/NADPH in Living Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Proteome-Wide Analysis of Cysteine Oxidation Using SICyLIA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dynamic Crystallography Studies of Protein Thiol Switches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanisms of Redox Signaling in Aging
6:00 pm - 6:20 pm
"Selenium, Redox and Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Effects of Developmental ROS on Stress Resistance and Lifespan"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Homeostatic Redox Balance and Epigenetic Changes During the Cellular Transition to Stem Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Redox Regulation of Autophagy Extends Lifespan in Drosophila "
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"GSNOR Links S-Nitrosylation to the Mitochondrial Theory of Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Dysregulation of Redox Signaling in Age-Related Disease
9:00 am - 9:20 am
"Ferroptosis Mechanisms and Pharmacological Tractability in Degenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Dynamic Redox-Based Control of Tyrosine Kinase Signaling in Health and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Probing In Vivo Oxidant Pathways in the Cardiovascular System Using Chemogenetic Approaches"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Integrated Redox Analysis of Head and Neck Cancer Reveals New Opportunities for Diagnosis and Treatment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Redox-Controlled Boundaries of Physiological and Pathological Responses at a Replication Fork"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Characterization of PYROXD1, a Novel Redox-Redulator of tRNA Splicing"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Accumulated Succinate Controls Mitochondrial ROS Production to Activate Adipose Tissue Thermogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Dark Side of the Moon: Membrane Thiols Cause Premature Aging In Vivo "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pharmacological Manipulation of Redox Signaling
6:00 pm - 6:20 pm
"Anticancer Potential of Cell-Specific Redox Effects by Drugs Targeting Thioredoxin Reductase 1"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Manipulating Mitochondrial Thiol Redox Status In Vivo "
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Redox Diversity Breeds Drug Tolerance in Mycobacterium tuberculosis "
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Redox Regulation of the Oncogenic KRas G12C Mutant"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Targeting the oxPPP: Discovery and Characterization of Cell-Active G6PD Inhibitors"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Thiol Peroxidases in Redox Signaling
9:00 am - 9:20 am
"Disulfide Formation Kinetics of Two-Cysteine Peroxiredoxins and a Model for Peroxide Sensing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Multiple Possibilities for Peroxiredoxin Involvement in Redox Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Peroxiredoxins Facilitate the Oxidation of Thiols in Target Proteins Through Distinct Mechanisms"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Using Fission Yeast to Study Oxidative Stress in Toxicity and Signalling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel Structural Insights into the Rearrangements Required for the Disulfide-Bond Formation Step of Peroxiredoxins"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Potential Role for H2 O2 and Peroxiredoxins in Regulating Cellular Time-Keeping"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Exploring a Putative Redox Relay Between Peroxiredoxins and the Cytoskeletal-Regulatory Protein CRMP2"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Using Peroxidases to Enhance Oxidative Folding in E. coli "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Oxidative Stress Resistance and Damage Control
6:00 pm - 6:20 pm
"Integration of Hydrogen Peroxide Stress in Single Dividing Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Disulfide Bonds: A Crucial and Neglected Target for Biological Oxidants"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Mother Nature Invented Glutathione: But Why So Much? Principles and Open Questions in Glutathione Metabolism"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Profiling of Redox-Dependent Heterogeneity in Single Cells"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Enzyme-Catalysed Cysteine Oxidation and Its Role in Plant Flood Tolerance"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Redox Control Across Membranes and Compartments
9:00 am - 9:20 am
"Molecular Mechanisms to Maintain Cellular Redox Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reversing Redox Modifications in the Mammalian Endoplasmic Reticulum"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Regulation of Oxidative and Proteasomal Stress Responses at the ER"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Redox Nanodomain Mediated Signaling at ER-Mitochondrial Contact Sites"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Physiological Functions of Golgi and Extracellular Disulfide Bond Formation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Regulation of Thiol-Mediated Protein Quality Control in the Early Secretory Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Switch-off Mechanism to Protect the Mitochondrial Glutathione Pool from Oxidative Stress"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Reactive Sulfur Species and Their Biomedical Relevance
6:00 pm - 6:20 pm
"The Role of Hydrogen Sulfide in Endothelial Cell Energy Metabolism and Angiogenesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Speciation of Reactive Sulfur Species and Their Reactions with Alkylating Agents: Do We Have Any Clue About What Is Present Inside the Cell?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"The Chemical Biology of Hydropersulfides and Related Polysulfides: Possible Cellular Protectants"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Waves of Protein Persulfidation: From Signalling to Aging"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Aquaporin-8 Gating by Persulfidation: A Spillway to Route H2 O2 Signalling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure