Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: A Translational Career in Thrombosis and Hemostasis
Discussion Leader: A. Valance Washington (Oakland University, United States)
3:45 pm - 4:15 pm
Michael Holinstat (University of Michigan, United States)
"Partnering With Industry to Successfully Translate Scientific Discoveries Into Clinical Applications"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Thrombosis and Hemostasis: The Cellular and Coagulation Crosstalk and Beyond
Discussion Leader: Abigail Ajanel (Washignton University in St Louis, United States)
7:30 pm - 7:50 pm
Daniëlle Coenen (University of Kentucky, United States)
"Contribution of Platelet Granule Cargo Uptake and Secretion to the Initiation and Progression of Aortic Aneurysms"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
Dante Disharoon (Case Western Reserve University, United States)
"Detection of Hemostatic Impairment Caused by Platelet Number and Function Defects Using Platelet-Specific Dielectric Coagulometry"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Izabella Andrianova (PhD, United States)
"PAR1, But Not PAR4 Regulates Platelet Activation Through Downregulation of cAMP Levels Mediated by PDE3A"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Shayan Askari (Cardeza Foundation for Hematological Research, Thomas Jefferson University, United States)
"Roles of ADAM17 Translation in Platelet Function"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Guadalupe Rojas-Sanchez (Bloodworks Northwest, United States)
"Autophagy Shapes Platelet Function in Inflammatory Diseases"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cellular Basis of Hemostasis
Discussion Leaders: Marvin Nieman (Case Western Reserve University, United States) and Andre Lira da Silva (Oregon Health and Science University, United States)
9:00 am - 9:20 am
Yui Chun Wan (Duke University, United States)
"Targeting Gardos Channel to Regulate Lipid Scrambling in Red Blood Cells"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Vishal Srivastava (Cleveland Clinic, United States)
"Ribosomal Readthrough as an Alternative Therapy for Hemophilia Patients with Nonsense Mutations"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Murat Yaman (University of Michigan, United States)
"Drug Library Screening Reveals Proton-Pump Inhibitors as Potential Modulators of Thrombosis in Zebrafish Models"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
Yaqiu Sang (UNC Blood Research Center, United States)
"Loss of Fibrinolytic Activity Does Not Increase Venous Thrombus Formation in Mice"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Noa Linthorst (Leiden University Medical Center, The Netherlands)
"Targeted Mass Spectrometry to Identify Wild-Type and Mutant Von Willebrand Factor in a Von Willebrand Disease Type 2B Mouse Model"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Cellular Basis of Hemostasis: Navigating Careers in Biomedical Science
Discussion Leader: Gow Arepally (Duke University School of Medicine, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Cellular Basis of Hemostasis: Navigating Careers in Biomedical Science
Sol Schulman (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
Dafna Groeneveld (BioMarin, United States)
Lakmali M Silva (Harvard School of Dental Medicine, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes