Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Oxidative Stress and Disease: A Complex Systems Approach
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Oxidative Stress in Health and Disease: A Molecular Interaction Network Perspective"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Oxidative Stress in Biology and Medicine: From Biomarkers of Damage to the Redox Interactome"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomics, Mitogenomics and Metagenomics of Neurodegeneration and Oxidative Stress
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Heterogeneity Across Human AD Coexpression Modules Identified by Meta-Analysis of the Human Brain Transcriptome"
9:40 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Integration of Autophagy with Metabolic and Redox Regulation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Anavex 2-73 Patient Selection Biomarkers for Precision Medicine in Alzheimer's Disease"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Genomic Study of Oxidative Stress Response Using a Multi-Species Model"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Assessment of Therapeutic-Induced Neurotoxicity in a Brain Microphysiological System Using Untargeted Metabolomics and Targeted Molecular Biomarkers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The Epitranscriptomic Writer Alkbh8 Protects Against Reactive Oxygen Species and Environmental Stress"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Adaptations to Oxidative Stress in Complex Systems
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"NRF2 Addiction in Cancer Cells and Its Impact on Sulphur Metabolism"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Restoring the Cellular Redox Homeostasis by Pharmacological Activation of Transcription Factor Nrf2"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Memory of Oxidative Stress: Epigenetics in Aging
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Redox-Mediated Regulation of Healthspan"
9:40 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Nutrition- and Redox-Related Biomarkers of Aging"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Metabolic Signatures of Mating, Sex Peptide and Mifepristone in Drosophila "
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Selenium Deficiency Is Associated with Pro-Longevity Mechanisms"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Investigations into the Role of SKN-1B in C. elegans "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redox Dilemmas of Cell-Based Therapeutics
7:30 pm - 8:00 pm
"Mitochondrial Regulation of Hematopoietic and Leukemic Stem Cells: New Insights into the Stem Cell Dormancy"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Heterogeneity in Mitochondrial Redox Regulation and Its Impact in Cancer Therapy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"iPSC-Driven Drug Discovery of OXPHOS Diseases"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Thiol Redox Systems: Their Roles in Inflammation, Fibrosis and Cancer
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Pragmatic Considerations for Preclinical Studies of Endogenous Antioxidant Inducing Therapies"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
"Integrative Omics of Environmental Metals"
10:25 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:40 am
"Disulfide Reductase-Deficient Mouse Liver Models Reveal Insights on Oxidative Stress in Cancer"
11:40 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"MYC Activation Confers Oncogenic Stress Through RNA Decay, Ribonucleotide Catabolism and ROS"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Redox Metabolome and Transcriptome in Metabolic Disease Phenotyping
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Redox Lipidomics in Skin Aging Research"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Changes in miRNA Biogenesis and Their Impact on Metabolic Diseases and Aging"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Redox Proteome and Lipidome in Cardiovascular Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"The Functional Oxylipidomics of Blood Clotting"
9:40 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Investigating Redox-Based Mechanisms in Anticancer Drug Sensitivity/Resistance"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Nox4-ROS Mediate Mitochondrial Adaptation to Exercise"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Insights into the Role of Glucose Metabolism in Cardiac Health"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Stoichiometric Quantification of Thiol-Based Redox Modifications in Mouse Skeletal Muscle in Response to Exercise Adaption and Mitochondrial Oxidative Stress"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Frailty Factors and Interventions Using Omics Approaches
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Biomarkers, Signatures and Interventions in Aging"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Redox Biology Mechanisms Involved in Axonal Outgrowth"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Frailty Factors and Investigations Using Omics Approaches"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"BCL-xL and FAS Expression, Increase Longevity-Related Genes in Flies"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
General Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure