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Chromosome Dynamics
Gordon Research Conference

The Cellular, Molecular and Physical Biology of Chromosomes

Dates

May 21-26, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Rebecca Heald

Vice Chair:
John F. Marko

Meeting Description

Chromosomes provide the blueprint for all life. Because of its fundamental importance, chromosome biology is currently investigated by a large and diverse set of researchers using many different organisms, model systems, and approaches. The primary goal of this Gordon Research Conference on "Chromosome Dynamics" is to bring together a cross section of these researchers who represent the breadth and highest scientific standards within the field. Many discoveries have occurred and new technologies have developed in recent years at a very rapid pace. This conference allows researchers in diverse areas to learn about the current approaches and the latest experiments, and to develop interdisciplinary interactions and collaborations.

Related Meeting

This GRC was held in conjunction with the "Chromosome Dynamics" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Diverse Views of Chromosome Biology
Discussion Leader: Rebecca Heald (University of California, Berkeley, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmTatsuya Hirano (RIKEN, Japan)
"Condensin-Based Chromosome Organization"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmDaniela Barilla (University of York, United Kingdom)
"Chromosome Segregation in Archaea: A Thermophilic Menage a Trois"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmXiaowei Zhuang (Harvard University / Howard Hughes Medical Institute, USA)
"Imaging the Three-Dimensional Genome Organization in Single Cells"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Organization
Discussion Leader: David Sherratt (University of Oxford, United Kingdom)
9:00 am - 9:20 amIsabelle Vallet-Gely (Institut de Biologie Integrative de la Cellule, CNRS, France)
"Interplay Between Chromosome Segregation, Replication and Cell Division in Pseudomonas aeruginosa"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMichael Laub (Massachusetts Institute of Technology, USA)
"Regulation of Transcription and Replication by Nucleoid-Associated Proteins"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNancy Kleckner (Harvard University, USA)
"Global Chromosome Dynamics from Bacteria to Mammalian Cells"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amHironori Niki (National Institute of Genetics, Japan)
"Actively Transcribed rRNA Genes Contribute to Nucleoid Resolution in Bacillus subtilis Due to Binding of the Smc-ScpAB Condensin Complex"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amWendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"Chromosome Unfolding and Gene Regulation by Distant Enhancers"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmKiyoshi Mizuuchi (National Institutes of Health, USA)
"Intracellular Long-Range Communication and Chromosomal Positioning Mechanisms in Cell Division"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAndres Cardozo Gizzi (Centre de Biochimie Structurale, CNRS, France)
"Cell-Specific Long-Range Low-Frequency Interactions Regulate the Higher-Order Architecture of the Drosophila Genome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Abby Dernburg (University of California, Berkeley, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCentromeres, Telomeres and Chromosome Stability
Discussion Leader: Susan Lovett (Brandeis University, USA)
6:00 pm - 6:20 pmJulie Cooper (National Cancer Institute, NIH, USA)
"Noncanonical Roles of Telomeres and Centromeres in Controlling the Cell Cycle"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmTalk Selected from the GRS
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmMichael Lampson (University of Pennsylvania, USA)
"Preventing Chromosome Instability: Molecular Mechanisms of Mitotic Error correction"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSimona Giunta (The Rockefeller University, USA)
"Mechanisms to Maintain Centromere Stability in Human Cells"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmEros Lazzerini Denchi (The Scripps Research Institute, USA)
"TZAP: A Novel Telomere-Associated Protein Involved in Telomere Length Control"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmBarbara Funnell (University of Toronto, Canada)
"The Dynamics of ParA-DNA and ParA-ParB Interactions During P1 Plasmid Partition"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Biophysics
Discussion Leader: Kerry Bloom (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amSophie Dumont (University of California, San Francisco, USA)
"Mechanical Architecture and Function of the Mammalian Spindle"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJohan Elf (Uppsala University, Sweden)
"Coordination of Replication and Division Cycles"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amGeeta Narlikar (University of California, San Francisco, USA)
"Phase-Separation Behavior of Heterochromatin Suggests New Avenues for Cancer Therapeutics"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amEdward Banigan (Northwestern University, USA)
"Chromatin Is a Major Determinant of Nuclear Mechanics and Morphology"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amPaul Wiggins (University of Washington, USA)
"Modeling Replication Conflicts and Segregation Dynamics"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmXiaoliang Sunney Xie (Peking University, China)
"Chromosome Dynamics Probed by Single-Molecule Enzymology and Single-Cell Genomics"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmStephan Gruber (University of Lausanne, Switzerland)
"Structure of Full-Length Smc and Rearrangements Required for Chromosome Organization"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenome Structure and Dynamics
Discussion Leader: Jorge Schvartzman (Spanish National Research Council (CSIC), Spain)
6:00 pm - 6:20 pmHoura Merrikh (University of Washington, USA)
"Replication-Transcription Conflicts"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJade Wang (University of Wisconsin-Madison, USA)
"The Nature of Mutations Induced by Replication-Transcription Conflict"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmBarbara Meyer (Howard Hughes Medical Institute / University of California, Berkeley, USA)
"Role of Chromosome Structure in the Regulation of X-Chromosome-Wide Gene Expression"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmJennifer Gerton (Stowers Institute for Medical Research, USA)
"Replication Stress Restricts Ribosomal DNA Copy Number"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmCees Dekker (Kavli Institute of Nanoscience Delft, The Netherlands)
"Direct Imaging of the Circular Chromosome in E. coli"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromosome Dynamics and Cancer
Discussion Leader: John Marko (Northwestern University, USA)
9:00 am - 9:20 amJob Dekker (University of Massachusetts Medical School, USA)
"Folding and Segregating Chromosomes: Implications for Genome Stability and Epigenetic Inheritance"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGary Karpen (Lawrence Berkeley National Laboratory, USA)
"Is Heterochromatin Just a Phase?"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDaniel Gerlich (Institute of Molecular Biotechnology, Austria)
"Regulation of the Mitotic Chromosome Surface During Nuclear Assembly"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amNeedhi Bhalla (University of California, Santa Cruz, USA)
"Sizing Up the Spindle Checkpoint"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amSadie Wignall (Northwestern University, USA)
"Non-Canonical Mechanisms that Detect and Respond to Errors During Cell Division"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmAaron Straight (Stanford University School of Medicine, USA)
"RNA Dependent Control of Chromatin Silencing"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRaquel Oliveira (Instituto Gulbenkian de Ciência, Portugal)
"Condensin I Directs Sister Chromatid Resolution Throughout Metaphase"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMeiosis
Discussion Leader: Hironori Funabiki (Rockefeller University, USA)
6:00 pm - 6:20 pmElcin Unal (University of California, Berkeley, USA)
"Kinetochore Remodeling During Meiosis Through the Regulation of Hec1"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmScott Keeney (Memorial Sloan Kettering Cancer Center, USA)
"Spo11, a 'Broken' Topoisomerase"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmTomoya Kitajima (RIKEN Center for Developmental Biology, Japan)
"The Causes of Chromosome Segregation Errors in Mammalian Oocytes"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmJennifer Fung (University of California, San Francisco, USA)
"The Role of Telomerase Dependent Attachments in Ensuring Meiotic Chromosome Motion"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmYasushi Hiraoka (Osaka University, Japan)
"RNA-Associating Proteins Accumulated on the Chromosome During Homologous Chromosome Pairing in Meiosis"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmChromosome Cohesion and Condensation
Discussion Leader: Christian Haering (European Molecular Biology Laboratory (EMBL), Germany)
9:00 am - 9:20 amKikue Tachibana-Konwalski (Institut für Molekulare Biotechnologie (IMBA), Austria)
"Single-Nucleus Hi-C Reveals Unique Chromatin Reorganization During the Oocyte-to-Zygote Transition"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amHongtao Yu (University of Texas Southwestern Medical Center / Howard Hughes Medical Institute, USA)
"Structural and Mechanistic Insight into Cohesin Loading and Release"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amGordana Wutz (Research Institute of Molecular Pathology, Austria)
"Wapl, Pds5A and Pds5B Control Chromatin Compartments, TADs and Loops by Regulating Cohesin-DNA Interactions"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amDamien D'Amours (Institute for Research in Immunology and Cancer, University of Montreal, Canada)
"Fast Switches for a Slow Enzyme: Rescuing the Chromosome Condensation Machinery from the Chromatin Trap"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amClemence Hocquet (LBMC, École Normale Supérieure de Lyon, France)
"Role of Condensin in the Regulation of Gene Expression in Fission Yeast"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amCamilla Sjogren (Karolinska Institute, Sweden)
"The Smc5/6 Complex - Connecting DNA Supercoiling with Chromosome Segregation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKim Nasmyth (University of Oxford, United Kingdom)
"The Roles of HAWK Subunits in Loading, Maintaining, and Releasing Cohesin from Chromosomes"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMarkus Hassler (European Molecular Biology Laboratory, Germany)
"Structural Basis for Anchoring Eukaryotic Condensin to Chromosomes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmNorman Higgins (University of Alabama at Birmingham, USA)
"New Integral Components of the E. coli and Salmonella SMC Complex"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmChromosome Replication and Repair
Discussion Leader: Frederic Boccard (Institut de Biologie Integrative de la Cellule, CNRS, France)
6:00 pm - 6:20 pmStephen D. Bell (Indiana University, USA)
"Archeal DNA Replication"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmRevathy Ramachandran (National Institutes of Health, USA)
"A Mechanism of Replication Licensing in Bacteria: A Locus on Chr1 Licenses the Replication of Chr2 in Vibrio cholerae"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmJorge Schvartzman (Spanish National Research Council (CSIC), Spain)
"The Abundance of Fob1p Modulates the Efficiency of rRFBs to Stall Replication Forks"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmStephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"Regulation and Mechanism of Eukaryotic DNA Replication Initiation"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmAbby Dernburg (University of California, Berkeley, USA)
"A Compartmentalized Circuit Mediates Meiotic Crossover Control"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award number 1R13CA216679-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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