Gordon Research Conferences
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Conference Program
 
Brain Energy Metabolism & Blood Flow
August 12-17, 2012
Colby College
Waterville, ME
Chair:
Joseph C. Lamanna

Vice Chair:
Ute Lindauer

Related Meeting Information
The Brain Energy Metabolism & Blood Flow Gordon Research Conference was held in conjunction with the Brain Energy Metabolism & Blood Flow Gordon-Kenan Research Seminar. Please refer to the Brain Energy Metabolism & Blood Flow GKRS web page for more information.

Brain blood flow and metabolism are vital to the normal mammalian nervous system and provides the basis for functional imaging. Over the last decade, dramatic progress has been made in molecular biology, biophysics and genetics that impact our understanding of brain energy metabolism, neural organization, cell signaling and vascular regulation. In addition, new technologies have emerged to measure blood flow and metabolism with high spatial and temporal resolution. The stage is set to use the methodological progress to address fundamental issues related to the organization of brain function, blood flow and metabolic activity. We anticipate that progress in this field will drive new discoveries in the experimental and clinical neurosciences and impact diagnosis and treatment of stroke and other neurodegenerative disorder. The biannual Gordon Research Conference is devoted to presentations of frontline research of brain metabolism, cell signaling, cell-cell interactions and vascular regulation in the normal and injured brain. The conference is a unique opportunity for experts and newcomers alike to exchange state-of-the-art advances in methodology and concepts, as well as outline promising avenues for collaborative research. For the 5th GRC on Brain Energy Metabolism and Blood Flow, the overall general theme turns around oxygen, blood flow and mitochondria in normal and pathological brain function.


Contributors

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmMetabolic aspects of neuroprotection and conditioning
Discussion Leader: Costantino Iadecola (Weill Medical College at Cornell Univ.)
7:40 pm - 8:20 pmMiguel Perez-Pinzon (University of Miami)
"Metabolic arrest and preconditioning to protect the brain against ischemia"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmSarah Milton (Florida Atlantic University)
"Modulation of reactive oxygen species in the anoxia tolerant turtle"
9:15 pm - 9:30 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTissue stress and oxygen availability
Discussion Leader: Howard Prentice (Florida Atlantic University)
9:00 am - 9:40 amTony Lee (Tzu Chi University)
"Nitric oxide and cerebral vascular function"
9:40 am - 10:00 amDiscussion
10:00 amGroup Photo / Coffee Break
10:30 am - 11:10 amJang-Yen (John) Wu (Florida Atlantic University)
"Mechanism of hypoxia induced neuronal injury and potential intervention strategy"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmGoran Nilsson (University of Oslo, Norway)
"Mechanisms of brain survival in the anoxic crucian carp"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeuroinflammation
Discussion Leader: Jaroslaw Aronowski (University of Texas, Houston TX)
7:30 pm - 8:10 pmSunghee Cho (Burke Medical Research Institute, Cornell)
"Role of CD36 in ischemic brain injury in hyperlipidemia: Targeting neuroinflammatory pathway"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmPaola Castri (NINDS/NIH)
"PARP-1 cleavage influences cell viability in an in vitro model of ischemia: how changing individual components of multiprotein complexes modulates inflammatory processes"
9:10 pm - 9:30 pmDiscussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIschemia-induced multiple organelle damage
Discussion Leader: Tibor Kristian (University of MD Baltimore)
9:00 am - 9:40 amBingren Hu (University of MD Baltimore)
"Protein aggregation and multi-organelle failure after brain ischemia"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amXin Qi (CaseWestern Reserve University)
"Regulation of mitochondrial dynamics in neurological injury: An implication for stroke therapeutics"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmRona Giffard (Stanford University)
"Gene therapy and organelle damage after brain ischemia"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnergy Substrate Metabolism
Discussion Leader: Michelle Puchowicz (Case Western Reserve Univ.)
7:30 pm - 8:10 pmJaime Ross (predoctoral fellow NIH / Karolinska Institute)
"Brain alterations in the prematurely aging mtDNA mutator mouse"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmUrsula Sonnewald (Norwegian Univ. of Science & Technology)
"Use of stable-isotope technology to measure brain metabolism; the Big Bang hypothesis and its solution
9:10 pm - 9:30 pmDiscussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTechnical Advances in Brain Oxygenation Measurement and Clinical Applications
Discussion Leader: Martin Wolf (Biomed. Optics Research Laboratory, ETH-Neuroscience Center, Zurich, Switzerland)
9:00 am - 9:40 amRobert DeLaPaz (Rockland Technimed)
"Potential Clinical Applications of Brain 17O MRI CMRO2 and OEF"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amTurgut Durduran (ICFO-The Institute of Photonic Sciences)
"Bench-to-bedside: Towards a comprehensive monitor of cerebral hemodynamics in clinical stroke management"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmJim Liu (University of New Mexico)
"Cerebral tissue oxygen level: role and function in ischemic brain injury and protection"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pmControl of Vascular Resistance in the Brain
Discussion Leader: Robert Bryan (Baylor Univ.)
7:30 pm - 8:10 pmMarilyn Cipolla (Univ. of Vermont)
"Sex-specific effect of hypertension on remodeling and vascular resistance in the brain"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmSean Marelli (Baylor Univ.)
"Role of endothelial transient receptor (TRP) channels in EDH-mediated vasodilation in the brain"
9:10 pm - 9:30 pmDiscussion
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEnergy Metabolism & Microcirculation in Cerebral Ischemia & Spinal Cord Injury
Discussion Leader: Gary Rosenberg (Univ. of New Mexico)
9:00 am - 9:40 amR. Chris Crumrine (Grifols Therapeutics, Inc.)
"Designing models of stroke to evaluate efficacy and safety of novel thrombolytic agents"
9:40 am - 10:00 amDiscussion
10:00 amCoffee Break
10:30 am - 11:10 amJuan Carlos Chavez (Biogen-Idec)
"The HIF-1/2 signaling pathway in cerebral Ischemia"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmRichard Benton (Univ. of Louisville)
"Insights into molecular regulation of EC dysfunction in spinal cord injury"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 8:30 pmHot Topics: Last minute breakthroughs and selected presentations from posters
Discussion Leader: Ute Lindauer (Technical Univ. of Munich)
TBA
8:30 pm - 9:30 pmKeynote Lecture
Discussion Leader: Joseph C. LaManna (Case Western Reserve University)
8:30 pm - 9:10 pmWalter Boron (Case Western Reserve University)
"Gas Channels"
9:10 pm - 9:30 pmDiscussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

 
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